Development of synthetic electrochemical methodologies for the synthesis of novel DNA binding agents
Anthracycline derivatives have been previously synthesised and tested for their binding properties at RGU. The synthesis of new, more selective derivatives is subject to the development of more environmentally benign procedures employing synthetic electrochemistry.
Research Opportunities
Summary
The anthraquinone polycyclic system is the core molecular template of a class of DNA binding agents. The anthracyclines, produced by streptomyces bacteria, have long been known to efficiently bind to DNA. Amongst these tetracyclic anthraquinone derivatives, doxorubicin, daunorubicin and epirubicyn are compounds of clinical importance and are employed in the treatment of a variety of human tumours. Mitoxantrone is another efficient DNA binding agent, with antineoplastic properties, obtained by bis-substitution of the anthraquinone framework. However, both anthracyclines and mitoxantrone display a lack of binding selectivity, which is reflected in unwanted toxicity and restricts their therapeutic indices.
The application of electrochemistry to the synthesis of organic molecules is not a new strategy. An early example of synthetic electrochemistry was described by Hermann Kolbe in 1848. Electrochemical methodologies will be developed during the course of this project for the synthesis of novel anthraquinone derived DNA binding agents.
Supervisors
Discuss this further with the potential supervisor for this research degree:
- Dr Alberto Di Salvo
Research Themes
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About our Research Degrees
We welcome specific ideas from applicants for a potential research degree topic. The University offers a number of potential self-funded topics in each School which you could consider developing your research project around.
It is not unusual for a proposed research degree topic to evolve as you progress through the application stage and even your future studies. This ensures the best match of your academic/professional experience with that of your supervisory team.
Occasionally, the University will also advertise available funded studentships, for very specific topics or subjects:
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Entry requirements
Entry Requirements for Research Degrees
Normal entry requirements are a first or upper second class honours degree from a University of the United Kingdom, or from an overseas University, or degree equivalent qualification, subject to the approval of Robert Gordon University.
Applicants holding other qualifications shall be considered on their merits and in relation to the nature and scope of the proposed research programme.
Applicants will normally register for an MSc/PhD or MRes/PhD with transfer to PhD dependent on satisfactory progress. However, applicants who already possess a Master’s degree which includes a significant research component could be registered directly for a PhD, subject to a satisfactory research proposal, and clear evidence of research expertise.
Some Research Degree Topics require employment experience, research experience and/or transcripts for international qualifications.
Contact researchdegrees@rgu.ac.uk to see if you are eligible.
English Language
Any applicant whose first language or language of previous University-level instruction is not English must normally demonstrate competence in English. This should be a score of IELTS 6.5 with 6.5 in all elements, or an approved equivalent.
We accept a variety of in-country and secure English language tests, find out more:
Please note, some courses may require a higher standard of English than stated in this page. Contact researchdegrees@rgu.ac.uk for further information.
Fees & Costs
For Academic Year 2024/2025
UK/EU Students
- Full time - £4,786 per academic year
- Part time MPhil/PhD - £2,870 per academic year
- Part time MRes/MSc by research - £2,390 per academic year
International Students
- Full time - £19,450 per academic year
- Part-time MPhil/PhD - £11,670 per academic year
- Part-time MRes/MSc by research - £9,720 per academic year
For Academic Year 2023/2024
UK/EU Students
- Full time - £4,712 per academic year
- Part time MPhil/PhD - £2,830 per academic year
- Part time MRes/MSc by research - £2,356 per academic year
International Students
- Full time - £18,700 per academic year
- Part-time MPhil/PhD - £11,220 per academic year
- Part-time MRes/MSc by research - £9,350 per academic year
Additional Costs
The following course-related costs are not included in the course fees:
- The cost of books that you may wish to purchase
- Accommodation and living costs
- Printing
Alumni Discount
Robert Gordon University is delighted to offer a 20% discount on course fees for all alumni who have graduated from RGU.
Scholarships and Financial Awards
Postgraduate research students will normally make their own arrangements for payment of fees. However you may qualify for a scholarship or financial award:
Funded Studentships
Occasionally, the University will also advertise available funded studentships, for very specific topics or subjects:
Disclaimer
For new intakes course fees are reviewed and published annually for each mode of delivery. Tuition fees are fixed for the duration of a course at the rate confirmed in the offer letter. For further information see:
How to Apply
Applications
All applications should be made via the University's online application for research students.
Before you apply, find out more about the application process, research proposal writing guides, routes and durations:
Our Research degrees usually start in February and October each year. There are no formal deadlines for you to submit your application, though we recommend you submit it as early as possible in order to ensure we can help you join us at your preferred time.
Completed application forms should be accompanied by:
- Degree certificate
- Statement of purpose, detailing why you would like to study this degree in the UK, and why you have chosen RGU.
- A short research proposal, in the range of 1,500 - 3,000 words, containing a rationale and background, study aims and objectives, a literature review, proposed research methods and a full reference list.
Further guidance on the application process:
English Language Requirements
All applicants whose first language is not from a recognised English speaking country will be asked to provide evidence of their English language skills as part of their offer to study at RGU.
Find out more about the English language qualification we accept:
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